β-arrestin-2 expressed in mast cells regulates ciprofloxacin-induced pseudo-allergy and IgE-mediated anaphylaxis.
Journal of Allergy and Clinical Immunology(2019)
摘要
The adapter protein β-arrestin2 inhibits Mrgprb2 and FcεRI-mediated mast cell degranulation to attenuate pseudo-allergy and anaphylaxis. Thus, targeting β-arrestin2 in mast cells could provide novel therapeutic options for modulating pseudo-allergy and anaphylaxis.
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关键词
Anaphylaxis,Ciprofloxacin,Mast cell,Pseudo-allergy,β-arrestin2
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