A receptor-guided design strategy for ligand identification.

Biomedical sciences require effective tools to manipulate, detect, and study biological phenomena. Oligo(deoxy)nucleotide ligands represent such tools, but the current strategies to generate them are restricted. Their limited availability is insufficient to address the broad range of targets related to biomedical research. Exemplified by targeting the hydrophobic molecule (-)-Delta(9)-tetrahydrocannabinol (THC), we report a receptor-guided design (RGD) strategy to generate chemically modified oligodeoxynucleotide libraries for the tailored selection of clickmers.