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Discovery of thiazolidin-4-one urea analogues as novel multikinase inhibitors that potently inhibit FLT3 and VEGFR2.

Baohui Qi,Xingwei Xu,Ying Yang,Yuting Zhou,Tao Chen,Guowei Gong,Xupeng Yue,Xin Xu,Liping Hu,Huan He

Bioorganic & Medicinal Chemistry（2019）

Cited 12|Views5
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Abstract
•Novel thiazolidin-4-one urea analogues were designed and synthesized.•17b was identified as a FLT3/VEGFR2 dual inhibitor.•17b induced cytotoxicity and suppression of migration, antiproliferation, apoptosis.
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Key words
Anti-tumor,Thiazolidin-4-one,FLT3,VEGFR2,Kinase inhibitor,Structure-activity relationship
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