Discovery of thiazolidin-4-one urea analogues as novel multikinase inhibitors that potently inhibit FLT3 and VEGFR2.
Bioorganic & Medicinal Chemistry(2019)
Abstract
•Novel thiazolidin-4-one urea analogues were designed and synthesized.•17b was identified as a FLT3/VEGFR2 dual inhibitor.•17b induced cytotoxicity and suppression of migration, antiproliferation, apoptosis.
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Key words
Anti-tumor,Thiazolidin-4-one,FLT3,VEGFR2,Kinase inhibitor,Structure-activity relationship
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