Collagen-derived X-Hyp-Gly-type tripeptides promote differentiation of MC3T3-E1 pre-osteoblasts

Yuki Taga,Masashi Kusubata,Kiyoko Ogawa-Goto,Shunji Hattori,Noriko Funato

Journal of Functional Foods（2018）

引用 19|浏览15

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摘要

•Ginger-degraded collagen hydrolysate (GDCH) contained X-Hyp-Gly-type tripeptides.•GDCH increased alkaline phosphatase (ALP) activity of MC3T3-E1 pre-osteoblasts.•X-Hyp-Gly enhanced ALP activity, mineralization, and collagen secretion of MC3T3-E1.•The osteogenic activities of X-Hyp-Gly were suggested to be exerted within the cell.

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关键词

Hyp,ALP,Runx2,GDCH,H-GDCH,NBT,BCIP,FBS,α-MEM,LC–MS,MRM,PBS,SI-collagen,Foxg1

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