Self-Assembling Behavior of Cysteine-Modified Oligopeptides: an XPS and NEXAFS Study
Journal of physical chemistry C/Journal of physical chemistry C(2018)
摘要
Achieving rigorous control over the procedures aiming at modifying surfaces by selective and covalent anchoring of bioactive molecules is a mandatory step in view of the realistic applicability of bioengineered materials in the field of tissue engineering, biosensing, and nanomedicine. In this context, we report here a proof-of-concept study carried out on a self-assembling peptide (SAP) functionalized with cysteine (Cys), as to ideally grant molecule grafting to gold surfaces. The effectiveness of the surface functionalization in a monolayer regime and the molecular stability of SAP-Cys were probed by X-ray photoelectron spectroscopy; the highly ordered self-organization attained by the grafting molecules was assessed by means of angular-dependent near edge X-ray absorption spectroscopy studies. This study opens wide perspectives for efficient chemical modification of surfaces with biomolecules to include bioactive motifs and/or to add nanometric fibrous patterns.
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