Differential peripherical biomarkers in severe mental illness

Introduction Patients with schizophrenia and bipolar disorder have higher rates of medical comorbidities and mortality than general population [1,2]. Aims To find severe mental illness biomarkers. Here, we present the peripherical biological parameters of patients with schizophrenia (SCH), bipolar disorder (BD) and healthy subjects (HS). Methods Cross-sectional, naturalistic study. Inclusion criteria: DSM-IV diagnosis of schizophrenia or bipolar disorder; ageu003e17 years; and written informed consent given. Results One hundred and twenty-three SCH, 102 BD and 80 HS. Laboratory tests: red cells, haemoglobin, leukocyte, platelets, glucose, urea, creatinine, uric acid, cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, GPT, AP, CA, P, FE, insulin, HbA1c and TSH. Age and gender were used as covariates. There were differences in: HDL-cholesterol ( P P P P =0.006) and TSH ( P =0.013). The differences were between SCH and HS (HDL-cholesterol, triglycerides, insulin, AP and TSH), and, between BD and HS (HDL-cholesterol, triglycerides, insulin and TSH), but not between SCH and BD. Conclusion There are differences in peripherical biological parameters between patients with SCH or BD and HS. Biological biomarkers may play a role in severe mental disorders pathogenesis [1,2].