GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) as a target for homologous and broadly neutralizing antibodies

•Epitope B in GP5 possesses the features of a broadly neutralizing epitope.•Accessibility to Epitope B is blocked by neutralizing and non-neutralizing antibodies.•Persistence is the result of escape from homologous neutralization.•Immune evasion can be explained by mutations in flanking hypervariable regions.