A low-noise and wide-bandwidth transimpedacne amplifier design for bionanopore applications

This paper presents a low-noise and wide-bandwidth transimpedance amplifier for bionanopore applications. Using a capacitive-feedback transimpedance amplifier for a headstage, the input-referred noise is drastically reduced, which enables one to accurately monitor DNA translocation. To achieve a wide bandwidth, an intermediator-and-differentiator structure and a split-resistor technique are proposed in this work.