Computed Tomography Role In Limited-Stage Lymphomas: Could We Reduce The Dose Of Radiation?
BLOOD(2014)
摘要
Lymphomas are the most frequent blood cancer. Current Lymphoma’s guidelines recommend initial staging and interim surveillance computed tomography (CT) scan, repeated every 6-12 mo for the first 2 years (ys) after end of treatment. Recent studies show that patients receiving 8 or more CTs have a 2-fold increase in secondary malignancies. This risk is dose-dependent. Cumulative exposure in excess of 75mSv has been estimated to increase cancer mortality by 7.3%. At present, more than 80% Hodgkin’s Lymphoma (HL) patients and more than 60% of NHL patients will be alive 5 ys after diagnosis. This percentage is higher in early stage disease (HL: 96 % overall survival (OS) at 5 ys; NHL: depends on the subtype, for DLBCL: 68-90 % at 5 ys). Considering this high survival rates and the demonstrated toxicity of radiation, avoiding CT scans overuse seems reasonable, especially in those with great chances of being cured.
更多查看译文
关键词
Computed Tomography,Cancer,Mantle Cell Lymphoma,Lymphoma,tumor
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要