Difference Of Metabolic Disturbance In Positional And Non-Positional Obstructive Sleep Apnea Syndrome

Objective: It is well known that obstructive sleep apnea-hypopnea syndrome(OSAHS) is associated with impaired glucose intolerance. We investigated that pattern of impaired glucose intolerance differs among patient with non-positional OSAHS and positional OSAHS. Design and method: We diagnosed OSAHS by overnight polysomnography study. And we assessed severity apnea-hypopnea index (AHI) and positonal apnea-hypopnea index difference. We defined positional OSAHS when supine-lateral index [(supine AHI- lateral AHI)/supine AHI] is more than 0.5. Insulin resistance was assessed with fasting plasma blood glucose, plasma insulin and homeostatic model assessment of insulin resistance index (HOMA-IR), leptin. Results: The respiratory disturbance index and lowest oxygen desaturation were higher in non-positional OSAHS group than positional OSAHS group. There were noted that impaired glucose tolerance and HOMA-IR were more increased in patient with severe OSAHS than control group and mild OSAHS. Compared with postional and non-positional OSAHS patients, impaired glucose tolerance and HOMA-IR were significantly increased in non-positional OSAHS group. Conclusions: Our result suggest that severe OSAHS is associated with glucose intolerance and non-positional OSAHS has a poor control of glucose than positional OSAHS group.