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术后病理性腹腔粘连小鼠模型粘连评价方法的实验研究

凌立君,曾莉, 林娜,王爱云,王峰,刘竟天,杨洪宝,易洪刚,潘立群,陆茵

Chinese General Practice（2004）

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Abstract
目的研究术后病理性腹腔粘连小鼠模型粘连评价方法的优选.方法采用清洁级昆明小鼠120只制作术后病理性腹腔粘连小鼠模型,随机分成5组(模型组和4个给药组),术后饲养14 d,于术后第15 d处死小鼠,各组均用四种腹膜粘连评分方法进行评分.结果Nair粘连评分法一及邱氏法评分结果5组之间腹膜粘连程度差异有显著性意义(P＜0.05),而Nair粘连评分法二、Phillips评分结果5组间腹膜粘连程度差异无显著性意义(P＞0.05).结论Nair粘连评分法一及邱氏法对术后病理性腹腔粘连小鼠模型的粘连评价较为适宜,其余两种均不适合.
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post-operative,intra-peritoneal
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