131 I-AG对内皮细胞生长抑制作用的研究
Medical Journal of National Defending Forces in Northwest China(2003)
Abstract
目的:评价血管生成抑制素(AG)、131I和131 碘标记的血管生成抑制素(131I-AG)对人脐静脉内皮细胞(HECV)生长的抑制作用.方法:体外原代培养新生儿ECV,采用MTT法观察131I-AG、AG、131I对其增殖的影响.结果:①与对照组比较,在(2~32)μg*ml-1时,AG对HECV生长抑制率为(7.4±5.4)%~(17.6±2.7)%(P<0.01);在放射性浓度<2.96 GBq*L-1时,131I对HECV的生长未见抑制作用,在浓度=3.70 GBq*L-1时,有抑制作用,其抑制率为11.51±2.7%(P<0.01);②用131I标记AG后,不同浓度的131I-AG对HECV生长抑制率分别为14.8%、17.3%、22.5%和31.4%,较131I与AG组明显提高(P<0.01).结论:①AG和131I对体外培养的HECV的生长均有抑制作用;②131I与AG偶联后,131I-AG对HECV生长的抑制有明显的协同作用,提示131I-AG在实体瘤治疗中有潜在的临床应用价值.
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Key words
Vascular Endothelial Growth Factor,endothelial cell behavior,anti-angiogenic therapy,endothelial progenitor cells
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