Synergy of polymyxin B, tigecycline and meropenem against carbapenem-resistant Enterobacter cloacae complex isolates.

Paola Hoff Alves,Roberta Taufer Boff,Afonso Luis Barth,Andreza Francisco Martins

Diagnostic microbiology and infectious disease（2018）

Cited 13|Views12

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Abstract

Here, we evaluated the combinations of antibiotics polymyxin B (PMB), tigecycline (TGC) and meropenem (MEM) by time-kill curves (TKC) against carbapenem-resistant Enterobacter cloacae isolates. Combination of PMB/TGC and PMB/MEM showed promising results in sub-inhibitory concentration of PMB indicating the possibility of reducing the dose of PMB used in the treatment.

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