Spatial Inhomogeneity of Cardiac Norepinephrine Transport Protein and Meta-[123I]Iodobenzylguanidine Uptake in Swine Myocardial Tissue

Claudia Kusmic,Assuero Giorgetti,Cristina Barsanti,Silvia Burchielli,Debora Petroni,Annette Kusch,Dario Genovesi,Luca Menichetti,Paolo Marzullo

Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging（2019）

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摘要

This study elucidates the expression of three different variants of NET proteins into the left ventricular myocardium of a healthy pig. NET expression into the LV was not homogeneous and paralleled by differences in regional [I]MIBG uptake. Moreover, the correlation and the agreement between measurements of regional expression of NET variants and [I]MIBG uptake represent a relevant finding for inferences about NET expression in the context of clinical imaging.

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关键词

NET,[123I]MIBG,CZT,Cardiac sympathetic innervation,Ultrafast cardiac camera

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