Lignans From Opuntia Ficus-Indica Seeds Protect Rat Primary Hepatocytes And Hepg2 Cells Against Ethanol-Induced Oxidative Stress
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY(2017)
Abstract
Bioactivity-guided isolation of Opuntia ficus-indica (Cactaceae) seeds against ethanol-treated primary rat hepatocytes yielded six lignan compounds. Among the isolates, furofuran lignans 4-6, significantly protected rat hepatocytes against ethanol-induced oxidative stress by reducing intracellular reactive oxygen species levels, preserving antioxidative defense enzyme activities, and maintaining the glutathione content. Moreover, 4 dose-dependently induced the heme oxygenase-1 expression in HepG2 cells.
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Key words
Opuntia ficus-indica, lignin, hepatoprotective activity, heme oxygenase-1
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