阻塞性睡眠呼吸暂停低通气综合征并2型糖尿病患者血清肿瘤坏死因子-α和血浆内皮素的变化及意义
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery(2016)
Abstract
目的:探讨肿瘤坏死因子-α(TNF-α)和血浆内皮素(ET)在阻塞性睡眠呼吸暂停低通气综合征(OS-AHS)合并2型糖尿病(T2DM)病理生理过程中的意义.方法:观察80例OSAHS患者(OSAHS组)、65例OS-AHS合并T2DM患者(OSAHS+T2DM组)、20例T2DM患者(T2DM组)、32名健康者(对照组).采用双抗体夹心酶联免疫吸附法检测上述4组研究对象的血清TNF-α和ET水平,比较OSAHS组与OSAHS+ T2DM组患者经持续正压通气(CPAP)或手术治疗3个月后的TNF-α、ET含量的变化.结果:OSAHS+ T2DM组血清TNF-α水平高于OSAHS组、T2DM组和对照组(均P<0.05);OSAHS组和T2DM组血清TNF-α水平高于对照组;OSAHS组和T2DM组之间血清TNF-α水平无差异;4组之间ET水平无显著性差异.在OSAHS组、OS-AHS+ T2DM两组中,血清TNF-α在治疗前后分别进行比较,差异均有统计学意义(P<0.05),其中OSAHS+T2DM组治疗前后比较有显著性差异(P<0.01),而OSAHS组、OSAHS+ T2DM两组ET在治疗前后比较均无差异(P>0.05).结论:TNF-α可能参与了OSAHS并T2DM的发生发展过程,而ET可能对OSAHS并T2DM的发生发展过程影响不大.
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Key words
diabetes mellites,serum tumor necrosis factor,plasma endothelium,osahs associated type
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