[Anti-Hypertensive Effect of Total Flavonoids of Cydonia Oblonga Leaves and Its Mechanism Based on Anti-inflammatory Function].

OBJECTIVE:To study the anti-hypertensive effect of total flavonoids of Cydonia oblonga leaves in spontaneously hypertensive rats, then to preliminarily investigate the mechanism of action based on anti-inflammatory function.METHODS:Spontaneously hypertensive rats were divided into six groups as spontaneously hypertensive control group (SHR), captopril group (25 mg/kg), Eucommia ulmoides group (30 mg/kg), total flavonoids of Cydonia oblonga leaves low (40 mg/kg), middle (80 mg/kg) and high dose (160 mg/kg) groups. Eight Wistar-Kyoto (WKY) rats were given distilled water as the control. The drugs were given by intragastric administration for 16 weeks, then the contents of IL-1β, IL-6, IL-10, TNF-α and CRP in rats serum were detected. The weight and the blood pressure of rats were measured at 0 min and 2, 4, 6, 8, 10, 12, 14, 16 weeks after drug administrated.RESULTS:Compared with control group, the contents of IL-1β, IL-6, TNF-α and CRP were increased and IL-10 was decreased; Compared with SHR group, the contents of IL-1β,IL-6, TNF-α and CRP were decreased in total flavonoids of Cydonia oblonga leaves groups.CONCLUSION:Total flavonoids of Cydonia oblonga leaves show an anti-hypertensive activity in spontaneously hypertensive rats and the mechanism is related to the function of anti-inflammatory.