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Evaluation of Polymorphisms in Angiogenesis-Related Genes As Predictive and Prognostic Markers for Sunitinib-Treated Metastatic Renal Cell Carcinoma Patients

Juana Dornbusch,Martina Walter,Andrea Gottschalk,Alice Obaje,Kerstin Junker,Carsten-Henning Ohlmann,Matthias Meinhardt,Aristeidis Zacharis,Stefan Zastrow,Olaf Schoffer,Marc-Oliver Grimm,Stefanie J. Klug,Manfred P. Wirth,Susanne Fuessel

Journal of cancer research and clinical oncology（2016）

Cited 22|Views27
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Abstract
Single nucleotide polymorphisms (SNPs) in angiogenesis-associated genes might play an important role in activity of the tyrosine kinase inhibitor sunitinib and could affect survival of cancer patients treated with this drug. The aim of this retrospective study was to elucidate the role of 10 known SNPs in VEGFA, VEGFR1, VEGFR2 and VEGFR3 as potential prognostic and predictive markers in an independent cohort of patients with metastatic renal cell carcinoma (mRCC).
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Key words
FLT1,FLT4,KDR,mRCC,SNP,Sunitinib,VEGFA,VEGFR
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