Preparation and in vitro study of hydrochloric norvancomycin encapsulated poly (d,l-lactide-co-glycolide, PLGA) microspheres for potential use in osteomyelitis.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY(2017)
摘要
HNV-loaded PLGA microspheres (HNV-PLGA MSs) were prepared by water-in-oil-in-water (w/o/w) double emulsion solvent evaporation technique. The surface of prepared HNV-PLGA MSs is smooth and nonporous with an average diameter of 69.9m. The drug-loading rate and encapsulation rate of HNV-PLGA MSs are 4.40 +/- 0.26% and 48.51 +/- 14.83%, respectively. Additionally, 43.36% of HNV was released from PLGA MSs after seven days of incubation. The antibacterial effects of HNV released from PLGA were as good as the pure HNV. HNV-loaded PLGA microspheres were successfully prepared using double emulsion solvent evaporation technique and their properties met the requirements for local anti-infection.
更多查看译文
关键词
Antibacterial effects,hydrochloric norvancomycin,poly (D, L-lactide-co-glycolide PLGA),solvent evaporation technique
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要