Stereoselective Synthesis Of A Dipyridyl Transient Receptor Potential Vanilloid-3 (Trpv3) Antagonist

Eric A. Voight,Jerome F. Daanen,Robert G. Schmidt,Arthur Gomtsyan,Michael J. Dart,Philip R. Kym

JOURNAL OF ORGANIC CHEMISTRY（2016）

引用 9|浏览25

暂无评分

摘要

An efficient asymmetric synthesis of dipyridyl TRPV3 antagonist 1 is reported. The four-step route involves two C-C bond-forming steps, a highly diastereoselective alkene hydration, and asymmetric ketone hydrosilylation in 97% ee.

查看译文

关键词

trpv3,stereoselective synthesis,receptor

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要