Liu Jun Zi Tang-A Potential, Multi-Herbal Complementary Therapy For Chemotherapy-Induced Neurotoxicity
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(2018)
摘要
Liu Jun Zi Tang (LJZT) has been used to treat functional dyspepsia and depression, suggesting its effects on gastrointestinal and neurological functions. LJZT is currently used as a complementary therapy to attenuate cisplatin-induced side effects, such as dyspepsia. However, its effect on chemotherapy-induced neuropathic pain or neurotoxicity has rarely been studied. Thus, we explored potential mechanisms underlying LJZT protection against cisplatin-induced neurotoxicity. We observed that LJZT attenuated cisplatin-induced thermal hyperalgesia in mice and apoptosis in human neuroblastoma SH-SY5Y cells. Furthermore, it also attenuated cisplatin-induced cytosolic and mitochondrial free radical formation, reversed the cisplatin-induced decrease in mitochondrial membrane potential, and increased the release of mitochondrial pro-apoptotic factors. LJZT not only activated the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha) promoter region, but also attenuated the cisplatin-induced reduction of PGC-1 alpha expression. Silencing of the PGC-1 alpha gene counteracted the protection of LJZT. Taken together, LJZT mediated, through anti-oxidative effect and mitochondrial function regulation, to prevent cisplatin-induced neurotoxicity.
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关键词
Liu Jun Zi Tang,cisplatin,neurotoxicity,mitochondria,PGC-1 alpha
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