The Correlation Between The Numerical Status Of Th22 Cells And Serum Level Of Il-22 With Severity Of Ulcerative Colitis
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY(2018)
摘要
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease, yet its etiology as well as pathogenesis remains poorly understood. There is increasing evidence that aberrant expression of CD4+T lymphocytes plays an essential role in the progression of different pathologies such as UC. This study aimed to evaluate the circulatory frequency of T-helper 22 (Th22), a subset of CD4+T cells, and serum level of its signature cytokine, IL-22, in patients with UC.Blood samples from 30 patients with UC and 30 controls (n=30) were tested for IL-22 level and circulatory Th22-cell count by ELISA and Flow cytometric analysis, respectively.Our results revealed higher serum level of IL-22 as well as circulatory frequency of Th22 cells in patients with UC compared to those in healthy controls. Notably, effective factors on severity of the disease were age, Th22, IL-22, ESR and CRP.We conclude that elevated circulating Th22 cells and their signature cytokine, IL-22, may be implicated in the pathogenesis of UC. These findings may provide preliminary experimental clues for the development of new therapies for UC and its severity judgment.
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关键词
Interleukin-22, Th22 cells, Ulcerative colitis
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