Simple determination of L-hydroxyproline in idiopathic pulmonary fibrosis lung tissues of rats using non-extractive high-performance liquid chromatography coupled with fluorescence detection after pre-column derivatization with novel synthetic 9-acetylimidazol-carbazole.
Journal of Pharmaceutical and Biomedical Analysis（2017）
摘要
•9-Acetylimidazol-carbazole was synthesized and used to label amino group of L-Hyp.•AIC exhibited high sensitivity and simplified derivatization conditions.•An HPLC-FLD method for determining L-Hyp in IPF and normal rat tissue was developed.
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关键词
AIC,DABSYL-Cl,DMAP,DMS-Cl,FMOC-Cl,HPAEC-PAD,IPF,L-Hyp,NBD-Cl,OPA,PITC
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