Ultrasound-responsive NIPAM-based Hydrogels with Tunable Profile of Controlled Release of Large Molecules.

•An ultrasound-responsive hydrogel based on N-isopropylacrylamide is proposed.•Ultrasound induces release of bovine serum albumin and dextran from the hydrogel.•Ultrasound increases the release through thermal and non-thermal effects.•A positive correlation between the ultrasound intensity and release amount exists.•Difference of release between presence and absence of ultrasound can be adjusted.