Effects of Implantation of Cryopreserved Placental Explants on the Behavioral Indices and Morphological Characteristics of the Cerebral Structures in Senescent Mice

The effects of implantation of cryopreserved placental explants (CPEs) on the behavioral phenomena were studied in adult young (6 months old) and in senescent (presenile ontogenetic period, 12 months old) mice; morphological characteristics of the cerebral structures were also examined in these animals. Implantation of CPEs significantly influenced the behavioral indices and adaptational capacities of senescent mice; the direction of such effects was sex-dependent. In male mice, manifestations of deadaptation (decreases in the mobility and exploration habits and an increase in anxiety) were observed, while in females the behavioral manifestations were opposite (positive). Implantation of CPEs led to partial smoothing of negative shifts in the morphological characteristics in the motor cortex and hippocampus of senescent mice. Therefore, CPEs can serve as a source of natural compounds and cell elements providing the activation of neurogenesis, formation of new neurons, and their proliferation in key structures of the brain. In prospect, CPE-based therapeutic agents can be used for the correction of age-related dysfunctions of the CNS.