On the Detection of Peripheral Cyanosis in Individuals with Distinct Levels of Cutaneous Pigmentation

Peripheral cyanosis, the purple or blue coloration of hands and feet, can represent the initial signs of life-threatening medical conditions such as heart failure due to coronary occlusion. This makes its effective detection relevant for the timely screening of such conditions. In order to reduce the probability of false negatives during the assessment of peripheral cyanosis, one needs to consider that the manifestation of its characteristic chromatic attributes can be affected by a number of physiological factors, notably cutaneous pigmentation. The extent to which cutaneous pigmentation can impair this assessment has not been experimentally investigated to date, however. Although the detection of peripheral cyanosis in darkly-pigmented individuals has been deemed to be impractical, data to support or refute this assertion are lacking in the literature. In this paper, we address these issues through controlled in silico experiments that allow us to predictively reproduce appearance changes triggered by peripheral cyanosis (at different severity stages) on individuals with distinct levels of cutaneous pigmentation. Our findings indicate that the degree of detection difficulty posed by cutaneous pigmentation can be considerably mitigated by selecting the appropriate skin site to perform the observations.