Total Synthesis of (+)-Pochonin D and (+)-Monocillin II Via Chemo- and Regioselective Intramolecular Nitrile Oxide Cycloaddition.
Organic letters(2017)
摘要
Asymmetric total syntheses of (+)-pochonin D (1) and (+)-monocillin II (2), Hsp90 inhibitors with potent anticancer activity, have been accomplished where the macrolactone 3 was constructed through a chemo- and regioselective intramolecular nitrile oxide cycloaddition of diene 4.
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