The Notch-3 receptor: A molecular switch to tumorigenesis?

•Deregulation of Notch-3 is associated with more aggressive, often chemo resistant malignancies.•Notch-3 acts as a molecular switch to a variety of biological processes including angiogenesis and the release from tumour dormancy.•Therapeutic strategies against Notch-3 are showing promise in preventing tumour growth alone or in combination with chemo- or radio-therapy.