The Notch-3 receptor: A molecular switch to tumorigenesis?
Cancer Treatment Reviews(2017)
Abstract
•Deregulation of Notch-3 is associated with more aggressive, often chemo resistant malignancies.•Notch-3 acts as a molecular switch to a variety of biological processes including angiogenesis and the release from tumour dormancy.•Therapeutic strategies against Notch-3 are showing promise in preventing tumour growth alone or in combination with chemo- or radio-therapy.
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Key words
Notch,Cancer,Biomarkers
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