Apelin Administration Improves Insulin Sensitivity in Overweight Men During Hyperinsulinaemic‐euglycaemic Clamp

Pierre Gourdy,Laurent Cazals,Claire Thalamas,Agnes Sommet,Fabienne Calvas,Monique Galitzky,Claire Vinel,Cedric Dray,Helene Hanaire,Isabelle Castan-Laurell,Philippe Valet

Diabetes, obesity & metabolism/Diabetes, obesity and metabolism（2017）

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摘要

Apelin is a recently identified adipokine known to improve glucose tolerance and insulin sensitivity in murine models. This study was dedicated to the proof of concept that apelin administration also enhances insulin sensitivity in humans.

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关键词

adipokine,apelin,APJ system,hyperinsulinaemic-euglycaemic clamp,insulin resistance,type 2 diabetes

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