Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

Laurel A Monticelli,Michael D Buck,Anne-Laure Flamar,Steven A Saenz,Elia D Tait Wojno,Naomi A Yudanin,Lisa C Osborne,Matthew R Hepworth,Sara V Tran,Hans-Reimer Rodewald,Hardik Shah,Justin R Cross,Joshua M Diamond,Edward Cantu,Jason D Christie,Erika L Pearce,David Artis

NATURE IMMUNOLOGY（2016）

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摘要

The cell-intrinsic pathways controlling the function of innate lymphoid cells are poorly defined. Artis and colleagues demonstrate that ILC2s selectively express arginase 1 and that this is critical for their bioenergetics, proliferation and function.

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关键词

Mucosal immunology,Enzymes,Innate lymphoid cells

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