L1-associated genomic regions are deleted in somatic cells of the healthy human brain

Jennifer A Erwin,Apuã C M Paquola,Tatjana Singer,Iryna Gallina,Mark Novotny,Carolina Quayle,Tracy A Bedrosian,Francisco I A Alves,Cheyenne R Butcher,Joseph R Herdy,Anindita Sarkar,Roger S Lasken,Alysson R Muotri, Fred H Gage

Nature Neuroscience（2016）

引用 148|浏览49

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摘要

The healthy human brain is a mosaic of varied genomes. Using a single cell sequencing approach targeting L1 elements, the authors show that the contribution of L1 to somatic mosaicism goes beyond retrotransposition and includes deletion of genomic regions associated with L1.

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关键词

Genetics,Neuroscience,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics

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