Baclofen ameliorates spatial working memory impairments induced by chronic cerebral hypoperfusion via up-regulation of HCN2 expression in the PFC in rats.

Pan Luo,Cheng Chen,Yun Lu,TianLi Fu,Qing Lu,Xulin Xu,Changjun Li,Zhi He,Lianjun Guo

Behavioural Brain Research（2016）

引用 23|浏览17

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摘要

•Baclofen could ameliorate spatial working memory impairment induced by CCH.•Baclofen could reverse the CCH-induced decrease of HCN2 expression in the PFC.•That HCN2 may target PV-interneurons is implicated in working memory processes.

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关键词

GABAB receptors,Chronic cerebral hypoperfusion,Spatial working memory,HCN subunits,PFC

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