OC12.04: Longitudinal changes of fetal biometries and cerebrovascular hemodynamics in fetuses with congenital heart disease

To determine the longitudinal behaviour of fetal biometries and cerebrovascular hemodynamics throughout gestation in fetuses with congenital heart disease (CHD). Fetal biometries and Doppler hemodynamics (uterine artery (UtA), umbilical artery (UA) and middle cerebral artery (MCA)) were serially performed in a cohort of consecutive fetuses diagnosed with CHD. Evaluations were performed at various points from diagnosis (< 25 weeks of gestation) to delivery, with at least 2 measurements performed for each fetus, at least 4 weeks apart. All parameters were transformed into z-scores. A linear mixed model to analyse repeated measures was performed for each parameter to assess their behaviour throughout gestation. A total of 444 ultrasound evaluations were performed on 119 CHD fetuses, with a median of 2 measurements per fetus. CHD fetuses showed a small head at diagnosis (BPD −1.32 ± 0.99 z scores, HC −0.79 ± 1.02 z-scores), maintained throughout gestation (figure a). UtA and UA Doppler showed an increase towards the end of pregnancy, whereas no changes were observed in MCA or cerebroplacental ratio (CPR) with gestational age (figure b). Supporting information can be found in the online version of this abstract Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.