Synthesis of new 2-substituted 3-(tri(di)fluoromethyl)quinoxalines from 3-(trifluoromethyl)quinoxalin-2(1 H )-one and 3-(tri(di)fluoromethyl)quinoxaline-2-carboxylic acids

Starting from 3-(trifluoromethyl)quinoxalin-2(1 H )-one, a wide range of new 2-substituted 3-(trifluoromethyl)quinoxalines were obtained, including amino, bromo, chloro, hydrazino, phenyl, α-furyl, formyl, methylsulfanyl, and methylsulfonyl derivatives. 3(Tri(di)fluoromethyl)quinoxaline-2-carboxylic acids were obtained for the first time and used for the synthesis of 2-amino-3-(tri(di)fluoromethyl)quinoxalines and 2-(2-aminothiazol-4-yl)-3-(trifluoromethyl)quinoxaline. How to Cite Didenko, A. V.; Vorobiev, M. V.; Sevenard, D. V.; Sosnovskikh, V. Ya. Chem. Heterocycl. Compd. 201 5 , 51 , 259. [ Khim. Geterotsikl. Soedin. 2015 , 51 , 259.] For this article in the English edition see DOI 10.1007/s10593-015-1694-5