CHARACTERIZATION AND BIOCOMPATIBILITY OF PERFUSION-DECELLULARIZED HUMAN HEART MATRIX: TOWARD BIOENGINEERING PERFUSABLE HUMAN HEART GRAFTS

Pedro L. Sanchez,Ma Eugenia Fernandez-Santos,Salvatore Costanza, Hugo Rodriguez-Abella,Stefan Kren,Gregorio Garrido, Jose Luis Escalante, Rafael Matesanz,Doris Taylor,Fernandez-Aviles Francisco

Journal of the American College of Cardiology（2012）

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摘要

The current best treatment option for patients with end-stage heart failure is allograft heart transplantation, which is limited by donor source and immunorejection. Generating an autologous bioartificial heart could overcome these. Here we demonstrate perfusion decellularization of human whole

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