Bone status of acetylcholinesterase-knockout mice
International Immunopharmacology(2015)
Abstract
Acetylcholinesterase (AChE) hydrolyzes acetylcholine (ACh) to acetate and choline and thereby terminates nerve impulse transmission. ACh is also expressed in bone tissue and enhances here proliferation and differentiation of osteoblasts, which makes it interesting to investigate effects of AChE deficiency on bone. To our knowledge, this is the first study that analyzed bone of heterozygous acetylcholinesterase-knockout (AChE-KO) mice.
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Key words
Acetylcholinesterase,Bone,Knockout,Mouse
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