A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease

Fanfei Meng,Sajid Asghar,Shiya Gao,Zhigui Su,Jue Song,Meirong Huo, Weidong Meng,Qineng Ping,Yanyu Xiao

Colloids and Surfaces B: Biointerfaces（2015）

Cited 139|Views10

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Abstract

•A novel LDL-mimic nanocarrier (Lf-mNLC) was built for brain-targeted delivery.•The stability of Lf-mNLC in BCECs was evaluated through FRET analysis.•The brain-targeted activity of Lf-mNLC after intravenous administration was explored.•Pharmacodynamics of Lf-mNLC on the AD model of rats was evaluated.

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Key words

Lactoferrin,Carboxylated polyethylene glycol (100) monostearate,LDL-mimic nanostructured lipid carrier system,Brain targeting,Alzheimer's disease

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