Effects of Antimicrobial Peptide Cathelicidin (Ll-37) by 625 nm Led Irradiation in Porphyromonas Gingivalis Infected Immortalized Gingival Fibroblasts

SEVERE RECURRENT GINGIVAL HYPERPLASIA IN A 7-YEAR-OLD PATIENT Kate Parker, Muhammed Almomen, Peter Ayliffe, Robert Evans, Maxillofacial and Dental Department, Great Ormond Street Hospital, London, UK A 7-year-old boy has been managed at Great Ormond Street Hospital since infancy for severe recurrent gingival hyperplasia. The patient first presented at 18 months of age with severe gingival hyperplasia covering the upper and lower dentition, causing aesthetic and functional concerns. There was no family history of neurofibromatosis or other medical conditions associated with gingival hyperplasia. Medically, the patient has multiple sutural synostoses; however, no causes of the gingival hyperplasia were identified. Multiple gingivetcomies and the exposure of teeth have been performed over a period of 5 years. Histopathological diagnoses have alternated between juvenile hyaline fibromatosis and gingival fibromatosis, with the patient still being investigated for a confirmed aetiology. This case report outlines the diagnostic difficulties of this case and highlights the patient management and histopathological findings over a 5-year period. This is a rare case of paediatric severe recurrent gingival hyperplasia where the aetiology remains unknown.