Comparison of susceptibility of HIV-1 variants to antiretroviral drugs by genotypic and recombinant virus phenotypic analyses
International Journal of Infectious Diseases(2015)
Abstract
•Phenotypic susceptibilities to six antiretroviral drugs were measured using a high-throughput, multi-cycle, recombinant virus phenotypic assay.•For most cases, the genotypic and in-house recombinant virus phenotypic analyses yielded similar results, with a concordance rate of 84.2%.•The cut-off intervals for HIV-1 antiretroviral drugs may be extended to some extent.•The disparity in HIV-1 susceptibility poses a need to invest the clinical outcome of antiretroviral therapy of special individuals.
MoreTranslated text
Key words
HIV/AIDS,Antiretroviral therapy,Genetic mutations,Phenotypic drug resistance
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined