New Fluorogenic Benzothiadiazole and Benzoselenadiazole Reagents to Yield Environment-sensitive Fluorophores via a Reaction with Amines

We introduce 7-fluoro-4-N,N-dimethylaminosulfonyl-2,1,3-benzothiadiazole and 7-fluoro-4-N,N-dimethylaminosulfonyl-2,1,3-benzoselenadiazole as new fluorogenic reagents for amines. These reagents are nonfluorescent themselves and can easily react with nonfluorescent amines to produce environment-sensitive fluorophores. Herein, we report the synthesis of the new reagents and the fluorescence properties of the reagents and their amine derivatives as well as the reactivity of the new reagents toward amines.