Reprogramming in vivo th17 into th17/th2 by Sirp-α dendritic cells in the lungs
Allergy, Asthma & Clinical Immunology（2011）
Abstract
Background Dendritic cells (DCs) play a crucial role in the development of the adaptive immune response. Unbalance DC response can cause Th1, Th17 or Th2-mediated diseases. By in vitro manipulation, Th2 and Th17 cell lines can be reprogrammed into Th1. This highlights the notion of the plasticity of different populations of CD4 T helper cells. So far, the conversion of Th17 memory cells into Th2 cells has not been demonstrated in the tissues.
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Key words
Dendritic Cell,Bronchoalveolar Lavage,Airway Inflammation,Adaptive Immune Response,Lung Inflammation
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