Islet Transplantation for Type 1 Diabetes
Juntendo Medical Journal(2015)
Abstract
Decades of research have brought islet transplantation from the dream of few to the reality of many. This procedure started as an experimental method to treat type 1 diabetes mellitus, which features β-cell dysfunction due to auto immunity. The burden of complication in these patients is cumulative and has become a major health problem, despite the availability of insulin therapy. The procedure relies on a sequence of finely orchestrated procedures starting in the donor and followed by several steps to isolate high quality islets. Extensive research is nowadays focussed in improving islet engraftment by providing a more beneficial environment to newly transplanted cells, coupled by more effective immunosuppressive drugs to avoid allo and auto immunity. Excellent results are now a reality in the most specialized centers. Yet, further steps are required to transform this low-risk treatment in a widely available and long-lasting therapy for diabetics worldwide.
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Key words
diabetes mellitus
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