High-resolution genetic profile of viral genomes: why it matters
Current Opinion in Virology(2015)
Abstract
•Multiple DAAs against HCV infection have been developed.•Drug escape mutations can be a major cause of treatment failure.•High-resolution genetics allows discovery of essential domains as novel drug targets.•Exhaustive drug resistance profile facilitates next-generation drug development.•Drug resistance profile and quasispecies sequencing assist personalized medicine.
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Key words
viral genomes,genetic profile,high-resolution high-resolution
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