CXCR5 + CD8 + T cells are a distinct functional subset with an antitumor activity
LEUKEMIA(2019)
摘要
CXCR5 mediates homing of both B and follicular helper T (T FH ) cells into follicles of secondary lymphoid organs. We found that CXCR5 + CD8 + T cells are present in human tonsils and follicular lymphoma, inhibit T FH -mediated B cell differentiation, and exhibit strong cytotoxic activity. Consistent with these findings, adoptive transfer of CXCR5 + CD8 + T cells into an animal model of lymphoma resulted in significantly greater antitumor activity than CXCR5 − CD8 + T cells. Furthermore, RNA-Seq-based transcriptional profiling revealed 77 differentially expressed genes unique to CXCR5 + CD8 + T cells. Among these, a signature comprised of 33 upregulated genes correlated with improved survival in follicular lymphoma patients. We also showed that CXCR5 + CD8 + T cells could be induced and expanded ex vivo using IL-23 plus TGF-β, suggesting a possible strategy to generate these cells for clinical application. In summary, our study identified CXCR5 + CD8 + T cells as a distinct T cell subset with ability to suppress T FH -mediated B cell differentiation, exert strong antitumor activity, and confer favorable prognosis in follicular lymphoma patients.
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关键词
Cancer immunotherapy,Translational research,Medicine/Public Health,general,Internal Medicine,Intensive / Critical Care Medicine,Cancer Research,Oncology,Hematology
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