Impact of early GnRH antagonist administration on ovarian response and pregnancy outcome in IVF

Recently, it has been suggested to initiate the GnRH antagonist use earlier than the established fixed GnRH antagonist regimen to achieve a more synchronized follicular growth and lower exposures to FSH, LH, estradiol and progesterone. The objective of this study was to assess the impact of IVF cycle using early initiation of GnRH antagonist on follicular synchronization and pregnancy outcome comparing with those of GnRH antagonist flexible multi-dose protocol.