Enhanced production of l-serine by deleting sdaA combined with modifying and overexpressing serA in a mutant of Corynebacterium glutamicum SYPS-062 from sucrose

•Sucrose was found to be favorable for cell growth and l-serine accumulation.•The resulting mutant accumulated 65.4% more l-serine (11.0±0.25g/L).•This mutant harbors a better ability to consume sucrose.•serA modification led to dramatically increase in l-serine production.•The key to enhance l-serine production was the removal of the feedback inhibition.