Biglcan is Beneficial in Angiotensin II Induced Heart Failure by Preventing Cardiac Inflammation and Remodeling Improving LV Function and Mortality by Preventing Transdifferentiation of Myofibroblasts

Biglycan is a small leucine rich proteoglycan and is important for the structural integrity of the extracellular matrix, but also serves as a danger signal and triggers sterile inflammation. Whether biglycan is beneficial or delirious in angiotensin induced heart failure, a model were remodeling as well as inflammation plays a crucial role, is unkown. The present study investigated whether gene deletion of biglycan influences cardiac inflammatory stress response, adverse remodeling as well as apoptosis leading to cardiac dysfunction and mortality after 3 weeks of angiotensin induced heart failure in vivo.