Expression and Clinical Significance of MDM2 and P21waf1 Proteins in Human Glioma

Objective: To explore the expressions and clinical significance of murine double-minute 2 (MDM2) and p21WAF1 proteins in human glioma. Methods: The expressions of MDM2 and p21WAF1 proteins were, respectively, detected with immunohistochemistry S-P method in glioma and normal brain tissue, and then the relations of their expressions with clinical and pathologic parameters were analyzed. Results: The expressions of MDM2 and p21WAF1 proteins were significantly higher in glioma than in normal brain tissue (P<0.05). With the increase in the pathologic grading of glioma, MDM2 protein expression was significantly increased (P<0.05) and p21WAF1 protein expression was significantly decreased (P<0.05). The expressions of MDM2 and p21WAF1 proteins were related to survival rate and there was a correlation between MDM2 and p21WAF1 (P<0.05). Conclusions: MDM2 and p21WAF1 proteins play an important role in the genesis and development of glioma, and they may be used as indicators to assess the prognosis of glioma.