A Versatile Water-Soluble Chelating and Radical Scavenging Platform

Meital Eckshtain-Levi,Ronit Lavi,Dmitry S. Yufit,Bareket Daniel,Omer Green,Ohad Fleker,Michal Richman,Shai Rahimipour,Arie Gruzman,Laurent Benisvy

Chemical communications（2016）

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摘要

The phenol-diamide compound, 5-(tert-butyl)-2-hydroxy-N1,N3-bis(2-hydroxyethyl)isophthalamide (), is water-soluble, non-cytotoxic, and capable of both, trapping ROS species and chelating Cu(ii) and Fe(iii) ions; these combined properties confer a protective effect against ROS induced cell death.

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