Nuclear pore complex remodeling by p75 NTR cleavage controls TGF-β signaling and astrocyte functions

The authors show that changes in nuclear dynamics of p75 NTR by γ-secretase cleavage are a novel molecular switch that determines TGF-β signaling in astrocytes. Cleaved p75 NTR acts as a component of the nuclear pore complex, regulating nuclear import of Smad-2 in astrocytes. The authors find that p75 NTR is required in mice for TGF-β-induced glial scar formation and reduced neuronal activity.